Medicine

Harvard geneticist David Sinclair’s business pitch has remained largely the same: Aging can be slowed or reversed, and we are about to figure out how.

“A lot of my colleagues dislike that phrase, the reversibility of aging,” he told a roomful of longevity investors. “But I truly believe that, based on my lab’s research and now others, that aging can be reversed. If I can make one medicine that would change people’s lives, I’d be very happy.” Sinclair also has co-founded companies that sell directly to consumers products such as supplements and tests that purport to show one’s “biological age.” He has also helped raise more than $1 billion.

But according to a report in The Wall Street Journal, the investors have almost nothing to show for it. Four companies trying to develop longevity drugs have gone bankrupt or largely halted operations. Another four either haven’t yet tested their drugs or gene therapies in humans or have run only small-scale trials that make it difficult to know whether a drug will work.

Sinclair has drawn criticism from fellow scientists, who say he exaggerates the findings and implications of age-related research. The board of the Academy for Health and Lifespan Research, a group Sinclair co-founded and led, asked him to resign as president earlier this year after he was quoted as saying a dog chew sold by a company he co-founded reversed aging in dogs.

Possible Preaching Angles:

It looks like we’re still living in the reality of the Fall, that human beings will age, grow old, and eventually die. We are still mortal!

49.6 million. According to the Global Slavery Index that's the latest estimate for the number of slaves in the world today. It could be just another number in a blur of facts that fly by our faces in a day, but this nearly 50 million number has a face. It includes women and men, boys and girls who are held in bondage as sex slaves, domestic servants, and child soldiers.

Of course, that is only an estimate since slavery thrives in darkness. But another news item gives this statistic an even more horrifying angle. A British paper shared a story about “Daniel” (not his real name) who was brought into the U.K. for what he had been told was a "life-changing opportunity.” He thought he was going to get a better job. Instead, it was then that he realized there was no job opportunity and he had been brought to the UK to give a kidney to a stranger.

"He was going to literally be cut up like a piece of meat, take what they wanted out of him and then stitch him back up," according to Cristina Huddleston, from the anti-modern slavery group Justice and Care.

Luckily for Daniel, the doctors had become suspicious that he didn't know what was going on and feared he was being coerced. So, they halted the process.

Daniel was not free of his traffickers though. Back in the flat where he was staying, two men came to examine him. It was then he overheard a conversation about sending him back to Nigeria to remove his kidney there.

He fled, and after two nights sleeping rough, he walked into a police station near Heathrow, triggering an investigation that would lead to the UK's first prosecution for human trafficking for organ removal.

Despite international and domestic efforts, about 10 percent of all transplants worldwide are believed to be illegal—approximately 12,000 organs per year. For example, according to the World Health Organization as many as 7,000 kidneys are illegally obtained by traffickers each year around the world. While there is a black market for organs such as hearts, lungs, and livers, kidneys are the most sought-after organs … The process involves a number of people including the recruiter who identifies the victim, the person who arranges their transport, the medical professionals who perform the operation, and the salesman who trades the organ.

How many times have you heard expectant couples say, "Well, as long as our baby is healthy"? John Knight from Desiring God ministries cautions, "'Healthy' exists on a spectrum of possibilities just like disability. And that spectrum is becoming narrower with every passing year." He points to an article about University of Washington scientists who were able to identify the DNA sequence of a fetus with 98 percent accuracy, and with safer techniques.

The article noted, "The accomplishment heralds an era in which parents might find it easier to know the complete DNA blueprint of a child months before it is born. That would allow thousands of genetic diseases to be detected prenatally." That means that more children with disabilities will be aborted.

But Knight also argues that many people will be tempted to order up "designer babies"—all fueled by "an increasingly idolatrous mindset that says I have the right and the responsibility to determine what is best for me — including the physical and/or developmental makeup of my children, or somebody else's children."

Going to the doctor can seem tedious as a child and even as a teen, but it might surprise you to find out how long it really takes people to actually start taking their health seriously. According to a survey of 2,000 adults in the United Kingdom, people don’t start seriously monitoring their health until the age of 38—and often only after some sort of health scare.

The study found that starting to experience new aches and pains or reaching a milestone birthday were also among the triggers that encouraged them to take better care of themselves. Others were prompted to take action after a loved one passed away or experienced a health issue.

Celebrities also play a part in making people take notice of their health. Around one in 30 admitted that a famous person suffering a medical problem shocked them into taking things more seriously.

Following the announcement that King Charles is undergoing treatment for an enlarged prostate, the U.K. National Health Service’s webpage about the condition received 11 times more visits than the previous day—resulting in one person visiting the site every five seconds.

Dr. Elizabeth Rogers says, “It can be very easy to disregard your health – particularly when you are young or you feel that everything is OK. Sometimes it can take a bit of a wake-up call before you start taking your health more seriously, whether that is falling ill yourself or seeing a loved one or even a well-known person experience an issue.”

The study also found that nearly half (45%) of adults didn’t take much notice at a younger age as they felt broadly fine and 25% felt that nothing bad would happen to them. In hindsight, 84% feel they took their health for granted when they were younger, and 39% regret not taking more care of their health before they reached their mid-twenties.

Dr. Rogers adds, “Making even small changes to your exercise regime or diet can make a real difference to both your physical and mental health, as well as helping to prevent future conditions developing.”

Possible Preaching Angle:

At the beginning of the New Year people begin to give attention to their physical health. We might also take this occasion to ask Christians, “When did you start to take your spiritual health seriously?” When you are young it is easy to feel that it really isn’t necessary and that you have plenty of time, but later in life you will certainly regret not developing healthy spiritual habits of Bible reading, prayer, and church attendance.

While booze has, for thousands of years now, been the most socially acceptable form of self-medication, its many health detriments have pushed some to seek alternatives: shrooms, weed, pharmaceuticals, kratom, or some other wellness industry offering.

But why not just skip the drugs? What’s so bad about sobriety? In an article in Vox, Rebecca Jennings notes: “The world is really tough. The world has only gotten more anxiety-inducing and more challenging over the past decade or so. People are looking to numb out, they want to medicate their anxiety.”

But Jennings concludes with some startling observations about the movement, ones that point well beyond alcohol replacements:

There’s a dream that basically everyone in the world shares. It’s the dream of an alcohol that isn’t quite alcohol but almost is — a substance that will make you feel free and happy and sexy and chatty but also won’t get you addicted, won’t shave years off your life, won’t make you groggy and achy and anxious the next day. It’s the dream of a substance from which taking an entire month off as part of an annual challenge would be laughably absurd because why would anyone ever need a break from it?

Possible Preaching Angle:

If this sounds like the search for utopia, you’d be right. For her part, Jennings is deeply skeptical this utopia is ever possible: “Such a substance could never be more than fantasy because of course human beings would find a way to render it destructive.” But for Christians there is the always available, always effective promises of God (Psa. 23:1-3; Phil. 4:6-7).

Humans have been trying to chase away gray hair for millennia. Clay tablets from the Assyrian Empire dated to the 7th Century B.C. mention using the gall of a black ox, cypress oil, licorice, and honey to turn gray hair black.

Ancient Egyptians applied oil cooked with the blood of a black calf, according to the 3,500-year-old Ebers Papyrus. (Presumably, if it worked, we’d still be trying it).

Tech entrepreneur Bryan Johnson, who is spending millions experimenting on himself to slow aging, posted a YouTube video detailing his regimen to reverse hair loss and graying; the video has over 1.5 million views.

Johnson, 46, uses two topical treatments. One contains an herbal extract that, Johnson acknowledges, has colored his hair. But he says something is reversing his grays. When he has looked closely at plucked hairs, he says color has returned to some of them.

What is working? He isn’t sure. Johnson’s routine also includes more than 50 supplements daily and trips to a Honduran island for $25,000 gene-therapy injections.

One-third of U.S. adults said they would probably or definitely take a drug to prevent or reverse graying if such a medication were approved, according to a poll of 9,000 people. Some endorse gobbling black sesame seeds and blackstrap molasses to give gray hair the brush off. Others take liquid chlorophyll or douse their hair in onion juice. In online forums, posts about reversing grays can draw hundreds of replies.

Humans have been trying to chase away gray for millennia. Clay tablets from the Assyrian Empire dated to the 7th Century B.C. mention using the gall of a black ox, cypress oil, licorice, and honey to turn gray hair black. Ancient Egyptians applied oil cooked with the blood of a black calf, according to the 3,500-year-old Ebers Papyrus. (Presumably, if it worked, we’d still be trying it).

Tech entrepreneur Bryan Johnson, who is spending millions experimenting on himself to slow aging, posted a YouTube video detailing his regimen to reverse hair loss and graying; the video has nearly 700,000 views.

Johnson, 46, uses two topical treatments. One contains an herbal extract that, Johnson acknowledges, has colored his hair. But he says something is reversing his grays. When he has looked closely at plucked hairs, he says color has returned to some of them. What is working? He isn’t sure. Johnson’s routine also includes more than 50 supplements daily and trips to a Honduran island for $25,000 gene-therapy injections.

Medical clinics are popping up across the country promising to help clients live longer and better—so long as they can pay. Longevity clinics aim to do everything from preventing chronic disease to healing tennis elbow, all with the goal of optimizing patients’ health for more years. Clients pay as much as $100,000 a year for sometimes-unproven treatments, including biological-age testing, early cancer screenings, stem-cell therapies, and hair rejuvenation.

The centers capitalize on Americans’ obsession with living longer. Many doctors caution that some clinics’ treatments lack robust scientific evidence or introduce health risks. One researcher said, “Anybody who is treating your toenails can say they’re contributing to longevity.”

People who visit these clinics are often wealthy people in their 40s to 60s who are seeing signs of aging. Several providers say they have noticed clientele trending as young as 20-somethings in recent years.

The dramatic increase in life expectancy confuses people. In the United States at the turn of the twentieth century, the average life span was about 45 years. Now people are expected to live up to 78.5 years. That has spurred an unwarranted optimism, when in truth, the overwhelming majority of the increase is the result of a decrease in infant mortality.

At the turn of the twentieth century, about 10 to 15 percent of all children died before their first birthdays, mostly from infectious diseases. But because of medical advances, today less than one percent of children die before their first birthdays. Thus, Olshansky and Carnes point out in their book The Quest for Immortality, “The rise in the life expectancy has slowed to a crawl.”

Another thing that confuses people is thinking that if we could cure cancer, most of us would live many more years. Not true. In fact, Harvard demographer Nathan Keyfitz calculated that if researchers cured all forms of cancer, people would live only a measly 2.2 years longer before they died of something else! Unless science cures the majority of all diseases, as author Stephen Cave writes, “Then the result is not a utopia of strong-bodied demigods but a plethora of care homes and hospitals filled with the depressed, the diseased and the incontinent old.” In that case “it is not about living longer but dying slower.”

An article in Bloomberg Businessweek described the quest of multi-millionaire Bryan Johnson, a 45-year-old software entrepreneur, to turn back the clock. This year, he’s on track to spend at least $2 million on his body. He wants to have the brain, heart, lungs, liver, kidneys, teeth, skin, and hair of an 18-year-old.

The effort has been named Project Blueprint, and Johnson’s doing it with the assistance of 30 doctors. They try the most intriguing new treatments on Johnson and obsessively track the results using everything from whole-body MRIs to blood draws. It's all on top of a rigorous framework of a 1,977-calorie vegan diet, and an extremely specific brushing and flossing routine. If you think he's crazy, “This is expected and fine,” he says. The crazy part is, it's working.

According to the article, "Johnson’s body is, as they measure it, getting medically younger," citing the biological age of his heart (37), skin (28), lung capacity (18), and gum inflammation (17). Each morning starting at 5 a.m., Johnson takes two dozen supplements and medicines. There’s a supplement for artery and skin health, another to prevent bowel polyps, others to reduce inflammation, and also his vegan diet. He follows a daily hourlong workout, consisting of 25 different exercises. Then there are weekly acid peels to counteract sun damage and sound therapy to better his hearing.

Kristin Dittmar, a cancer specialist, says, “I think what he’s doing is impressive, and he has personally challenged me to be better. What he does is also essentially a full-time job.” She also stresses that cancer has genetic components that no cutting-edge science, let alone juices or creams, can yet beat.

It’s also easy to imagine how a group of Johnson wannabes experimenting with ever-riskier procedures could go horribly wrong.

Singer songwriter Willie Nelson has a long history of tempting, and cheating, death. In 1969, when his home in Ridgetop, Tenn., caught fire, he raced into the burning house to save two prized possessions, his guitar and a pound of “Colombian grass.” He has emphysema, the consequence of a near-lifetime of chain smoking that began in childhood, when he puffed on cedar bark and grapevines, before turning to cigarettes and then—famously, prodigiously—to marijuana.

In 1981, he was taken to a hospital in Hawaii after his left lung collapsed while he was swimming. He underwent a voluntary stem-cell procedure in 2015, in an effort to repair his damaged lungs. Smoking has endangered his life, but it also, he thinks, saved it: He has often said that he would have died long ago had he not taken up weed and laid off drinking, which made him rowdy and self-destructive.

Now, in his late 80s, he has reached the age where getting out of bed each morning can be construed as a feat of survival. “Last night I had a dream that I died twice yesterday,” he sang in 2017, “But I woke up still not dead again today.”

Anyone who has more money than they know what to do with eventually tries to cure aging. Google founder Larry Page has tried it. Jeff Bezos has tried it. Tech billionaires Larry Ellison and Peter Thiel have tried it.

Now the kingdom of Saudi Arabia, which has about as much money as all of them put together, is going to try it. The Saudi royal family has started a not-for-profit organization called the Hevolution Foundation. It plans to spend up to $1 billion per year of its oil wealth supporting basic research on the biology of aging and finding ways to extend the number of years people live in good health.

The sum, if the Saudis spend it, could make the Gulf state the largest single sponsor of researchers attempting to understand the underlying causes of aging—and how it might be slowed down with drugs. Former Mayo Clinic endocrinologist Mehmood Khan says, “Our primary goal is to extend the period of healthy lifespan. There is not a bigger medical problem on the planet than this one.”

Khan says the fund is authorized to spend up to $1 billion per year indefinitely. By comparison, the division of the US National Institute on Aging spends about $325 million a year on the biology of aging.

The Saudi government may be partially motivated by the belief that diseases of aging pose a specific threat to that country’s future. There is evidence that people living in the Gulf states “are aging faster biologically than they are chronologically.”

Basically, the country is being beset by diseases of affluence brought on by rich diets and too little exercise. Even though Saudi Arabia has a relatively young population, with a median age of around 31, it is experiencing increasing rates of obesity and diabetes.

Michael Wingard arrived at Houston Methodist Hospital with a cheerful "Howdy!" He's a young man with a healthy left kidney. In a couple of hours, a surgeon will remove the kidney and sew it into someone else's body. This also happens to be the day before his 20th birthday.

Michael's parents, Adrien and Ed, are with him, and they tear up as Michael is checked in. His mother said, “I'm very, very nervous and scared and all those emotions, but I'm so proud of him. He knew that his friend needed a kidney and he had to do whatever it took to make it happen.”

Michael Wingard's kidney isn't going to his friend, though, because he wasn't a match for her. But he was a match for someone else. And that's how Wingard became the first link in a 10-person chain that took place at Houston Methodist earlier this month.

In addition to Wingard, the swap involved:

Heather O'Neil Smarrella, who will get his kidney. Then her twin

Staci O'Neil gave her kidney to

Javier Ramirez Ochoa, whose son-in-law

Tomas Martinez, donated a kidney to

Chris McLellan, whose father

David McLellan, gave his kidney to

Barbara Moton, whose daughter

Lisa Jolivet, gave her kidney to

Kaelyn Connelly, Wingard's friend.

This 10-person procedure takes place over four days, and it's uncommon. Usually, the hospital has chains that involve up to six people. With all its complexities--from matching antibodies to patient health--a kidney swap of this size is hard to pull off. This one was postponed three times. But it's worth the effort. There are about 90,000 people on the transplant list, waiting for a kidney. Many will remain on the list for years. Some die waiting.

Two days after Michael Wingard's kidney surgery, a group of strangers gathered in a conference room at the hospital. Michael Wingard, Kaelyn Connelly, Heather O'Neil Smarrella, Staci O'Neil, Lisa Jolivet, Javier Ochoa, Tomas Martinez, and Chris McLellan sat around a conference table. And then they weren't strangers anymore. Chris McLellan leans over to Tomas Martinez: "Thank you for giving me my life back." And, he adds, "You have an awesome kidney."

Possible Preaching Angle:

You never know how your service to others, even to strangers, will radiate out into your community.

Snake oil was a real product. It was a traditional Chinese medicine that was brought to the United States in the 1800s by thousands of Chinese migrants who came to the country in order to find work building the Transcontinental Railroad. They brought with them their families, their culture, and their medicines. One of these was snake oil, extracted from Chinese water snakes, and used to treat arthritis and joint pain.

As word of the healing powers of Chinese snake oil grew, many Americans wondered how they could make their own snake oil here in the United States. Because there were no Chinese water snakes in the American West, many healers began using rattlesnakes to make their own versions of snake oil.

It was Clark Stanley, the self-styled “Rattlesnake King,” who successfully capitalized upon this. Stanley traveled across the United States, dressed as a cowboy, and put on shows. In front of a crowd, he would slice open a live rattlesnake and throw it into boiling water, and when the fats of the reptile rose to the surface, he would skim the top and bottle up the oil. Throngs of people lined up at his shows to buy the stuff.

Stanley claimed that he learned about the healing power of rattlesnake oil from Hopi medicine men. In 1893 he and his rattlesnakes gained attention at the World's Columbian Exposition in Chicago. Later he went on to establish production facilities in Beverly, Massachusetts and Providence, Rhode Island.

However, there was a problem with Stanley’s product: Stanley's Snake Oil didn't contain any snake oil at all. In 1917, federal investigators seized a shipment of Stanley's Snake Oil and found that it contained primarily mineral oil, fatty oil believed to be from beef, chili peppers, turpentine, and camphor. Stanley was charged for fraudulent marketing and fined $20.

Ever since then, the term “snake oil” has been established in popular culture as a reference to any worthless concoction sold as medicine, and has been extended to describe a wide-ranging degree of fraudulent goods, services, ideas, and activities such as worthless rhetoric in politics.

Just when pandemic-related misinformation was started to recede from public awareness, the Food and Drug Administration had to recently issue a warning against a new dangerous trend: misinformation resulting from viral video challenges. The latest concerned something called “NyQuil chicken.”

The FDA said in a press release, “A recent social media video challenge encourages people to cook chicken in NyQuil (acetaminophen, dextromethorphan, and doxylamine) or another similar over-the-counter cough and cold medication, presumably to eat. Social media trends and peer pressure can be a dangerous combination to your children and their friends, especially when involving misusing medicines.”

One of the reasons why the challenge is dangerous is that the chemical properties of NyQuil change when the liquid is heated to a boil, and high levels of the chemicals can be inhaled as vapors. An FDA spokesperson said, “The challenge sounds silly and unappetizing – and it is, Put simply: Someone could take a dangerously high amount of the cough and cold medicine without even realizing it.”

Parents can keep young people safe by following three common-sense practices:

Keep medicines away from children in a safe, inaccessible place.

Speak with children about the dangers of misusing pharmaceuticals.

Use all medications according to the directions given.

Possible Preaching Angle:

As Christians parents we need to protect our children from foolish pranks spread by social medial. Instead, in a supportive and loving way we should encourage our vulnerable children in wise living and thinking before they act on foolish trends.

Before the discovery of insulin, diabetes was a death sentence. Here’s the life-saving story of how scientists discovered insulin. The American Diabetes Association reports:

In 1889, two German researchers, Oskar Minkowski and Joseph von Mering, found that when the pancreas gland was removed from dogs, the animals developed symptoms of diabetes and died soon afterward. This led to the idea that the pancreas was the site where “pancreatic substances” (insulin) were produced. In 1910, Sir Edward Sharpey-Shafer suggested only one chemical was missing from the pancreas in people with diabetes. He decided to call this chemical insulin.

So what happened next? In 1921, a young surgeon named Frederick Banting and his assistant Charles Best figured out how to remove insulin from a dog’s pancreas. Skeptical colleagues said the stuff looked like “thick brown muck,” but little did they know this would lead to life and hope for millions of people with diabetes.

With this murky concoction, Banting and Best kept another dog with severe diabetes alive for 70 days. The dog died only when there was no more to extract. With this success, the researchers went a step further. A more refined and pure form of insulin was developed, this time from the pancreases of cattle.

In January 1922, Leonard Thompson, a 14-year-old boy dying from diabetes in a Toronto hospital, became the first person to receive an injection of insulin. Within 24 hours, Leonard’s dangerously high blood glucose levels dropped to near-normal levels.

Possible Preaching Angle:

The discovery of insulin, brought life to those near death, giving hope to those at death’s door. We are all sick with sin but the discovery of the gospel and Christ Jesus brings life, and hope.

A survey asked highly committed evangelicals what they thought of using gene editing to:

Treat disease at birth

An appropriate use of medical technology 52%

Taking medical technology too far 43%

Reduce disease over a lifetime

An appropriate use of medical technology 40%

Taking medical technology too far 58%

Make a baby more intelligent

An appropriate use of medical technology 5%

Taking medical technology too far 93%

The Department of Justice has filed charges against a father and his three sons for their role in illegally selling industrial bleach. The bleach itself is not an illegal substance, but according to officials, the family business consisted of fraudulently marketing the toxic chemicals as a miracle cure.

According to the criminal complaint, Mark Grenon of Bradenton, Fla, along with his adult sons, repeatedly told their customers that their “Mineral Miracle Solution” could cure not only COVID-19, but also various other aliments including malaria and cancer. According to a press release from the US Attorney’s office for the Southern District of Florida, "[The] FDA has received reports of people requiring hospitalizations, developing life-threatening conditions, and dying after drinking MMS."

The DOJ alleges that the Grenons sold thousands of bottles of the fraudulent solution, netting over $1 million in the process. They are also accused of attempting to operate as a religious nonprofit entity, the “Genesis II Church of Health and Healing,” for the purpose of avoiding government scrutiny and regulations.

The Grenons are charged with conspiracy to commit fraud, and also criminal contempt, because the government previously filed a civil suit to stop the sale of their product, which they ignored. Not only did they continue selling the toxic fake cure, but they sent a letter to the judge of the civil case informing him that they had no plans to comply with the court order. They also included threats of violence if the state were to try to enforce compliance.

The FDA has warned consumers not to purchase or consume MMS, explaining that it’s the same as drinking bleach and can cause serious side effects, including severe vomiting, diarrhea, and life-threatening low blood pressure.

Possible Preaching Angle:

All kinds of people make promises of wealth, prosperity, or healing. However, you can tell who's legit in part by the outcomes of their "ministry"--are people really healed or set free? Or is it a trick? God is about wholeness and integrity, not just headlines and spectacle.